We offer test compound purification, structure elucidation and physicochemical property measurement under one roof.
Fast automated and customized purification service of drug candidates and intermediates, using different methodologies including SFC, MS-guided automated preparative HPLC, separation of stereoisomers via chiral preparative HPLC.
Efficient and flexible in small sample single applications and/or batch-wise purifications of test compounds and intermediates.
Comprehensive structure elucidation expertise with standard and state-of-the-art techniques:
NMR (up to 600 MHz with cryo probe), for example: 1H, 13C, 15N, 19F, 31P; COSY, NOESY, HSQC, HMBC, STD-NMR, as well as Mass Spectrometry capabilities: ESI, EI, CI, UPLC/MS, LC/MS, GC/MS.
Optical methods supporting structure elucidation: IR, optical rotation, CD, UV/VIS.
Unique structure elucidation services applying long-standing expertise of our in-house experts on request.
We also offer distinct analytical services on demand.
In collaboration with our colleagues from Structural Biology we also perform crystal structure determination of small molecules, e.g. to determine the absolute configuration.
Measurement and interpretation of physicochemical parameters for target molecules. These methods include lipophilicity (logD), solubility (media, pH, formulations), stability (media, pH, stress, oxidative, light), ionization (pKa).