Open Science Probes

We enable Open Science.

Scientists at the Innovation Campus Berlin have contributed to Open Science Probes available via the Structural Genomics Consortium (SGC) to interrogate Biology.

Also in the future, Innovation Campus Berlin will actively participate in scientific networks and consortia to support Open Science.

 

Please find more information on:

https://www.thesgc.org/chemical-probes

 

Selected Publications on Open Science Probes with our contributions:

Werner, S., et al.(2019). Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile. J Med Chem 62(24): 11194-11217

Bouche, L., et al.(2017). Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J Med Chem 60(9): 4002-4022.

Fernandez-Montalvan, A. E., et al.(2017). Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action. ACS Chem Biol 12(11): 2730-2736.

Nguyen, D., et al.(2019). Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem 62(2): 928-940.

Hillig, R. C., et al.(2019). Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A 116(7): 2551-2560.

Eggert, E., et al.(2016). Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem 59(10): 4578-4600

Arrowsmith, C. H., et al.(2015). The promise and peril of chemical probes. Nat Chem Biol 11(8): 536-541.

Muller, S., et al.(2018). Donated chemical probes for open science. Elife 7.