Degrader Solutions

With decades of expertise in the field of biological research and drug discovery, NUVISAN provides a fully integrated protein degradation solutions encompassing a full range of PROTAC/Molecular Glue drug discovery services, utilizing cutting-edge technologies. Our services span both chemistry and biology, to align with your novel drug discovery goals. We offer packages that include a variety of tailored services covering the entire drug discovery process.

Our Degrader Solutions:

  • End-to-end degrader packages - from chemistry to biological insights
  • Direct-to-biology approach (100+ degraders/day)
  • A PROTAC library with >20 Ligands for E3s / >7000 linkers / >100 precursors
  • 3 million compound library with 1 billion in vitro/in vivo data points (HTS, virtual screening & data mining)
  • Availability of all assay formats for biochemical and cell-based assays for effective degrader screening flow 
  • State-of-the-art in vitro and in vivo models (AAALAC accredited)
  • >50 scientists + lab professionals (long-standing degrader experience/cross-functional integrated drug discovery)

Life Science Chemistry

We offer innovative strategies for the rapid discovery of PROTACs and molecular glues across all business models, including consulting, degrader design, fast library synthesis, and integrated projects from conception to success.

  • In silico tools supporting PROTACs and glues design
  • Ready-to-use collection of linkers and E3 binders
  • Fast synthesis & direct-to-biology
  • Multi-parameter optimization

Discovery Biosciences

Our platform encompasses all assay formats for cell-free and cell-based assays. We cover target engagement, ternary complex formation, target degradation, and mode-of-action analysis.

  • Biochemical: ASMS, SPR, TSA, X-Ray, HTRF, and NanoBRET 
  • Cell-based: HCA, HiBiT (CRISPR KI or OE), NanoBRET, AlphaLISA, Western Blot, and ProteinSimple
  • Proteomics for selectivity of degradation
  • Customer-specific assays / assay development services

In Vivo Pharmacology

Integrated pharmacology services, covering the entire drug discovery and development chain. We have various in vivo models available for different therapeutic areas to support:

  • Efficacy studies
  • Exposure studies
  • Biomarker studies correlating the PK-PD relationship
  • Formulation approaches to ensure bioavailability of compounds

DMPK (Drug Metabolism and Pharmacokinetics)

Our DMPK discovery bioanalysis services can support the stages of drug discovery, from lead confirmation and lead optimization to preclinical studies.  We offer a comprehensive range of services:

  • Pharmacokinetic (PK) and pharmacodynamic (PD) analysis
  • Toxicokinetic analysis
  • High-quality PK/PD assessments with industry-standard PK/PD analysis tools